TC, where have you been my whole life? This is why I love the GAF. I'm also a big fan of 2D cityscapes. For
years I've wanted someone to create a massive, sprawling, 16-bit dystopian city in which I could explore and beat up baddies (preferably Neo Tokyo. Basically just make me Akira the game). I've always envisioned some sort of side-scroller, but with a myriad of gameplay mechanics to give it a more modern feeling. Man, 2D art just packs so much soul, detail and character, it's hard not to love.
Not a game per say, but I always think of Danger's teaser video for his track 4h30. Such a badass vibe.
https://www.youtube.com/watch?v=N9ZkJm05XbI
There are some fantastic posts in this thread.