Nintendo anime huh......that would be cool
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Kid Icarus, Legend of Zelda, Xenoblade, or Fire Emblem would be the best fits for this for the following:
-Have an anime-like look that will naturally adapt to anime animation
-Stories could range from serious (Xenoblade, Fire Emblem), adventurous (Zelda) or humorous (Kid Icarus)
-Kid Icarus has a lot of potential with this to explode with popularity due to how funny the game was, anime for the game already produced (short animated clips prior to the games launch, ect) and it could have an amazing English localization just like Uprising got
-Zelda could be a grand adventure anime with a silent hero or mostly silent Link (styled/characterized like Jack from Samurai Jack) just exploring Hyrule, helping out the locals and exploring dungeons while on the hunt for the looming threat of Gannon. Zelda could be great character wise (doing actions, protecting the kingdom, ect) and Gannon could be a great multi-dimensional villain (give him a reason to want the triforce outside of power, have his connection to Gudo's be fleshed out, ect).
-Xenoblade and Fire Emblem could be like any type of action packed anime; large battles with army's, massive worlds to explore, ect. I wonder how the localization could be with this but it would be cool.