With an i5-3570k, 8GB of RAM and a GTX 1070, it seems like 60FPS simply isn't possible at 1440p. I set every setting as low as it would go, but upscaling off, and it was running at like 45-50ish and stuttering badly. In fact, it seems to stutter pretty much constantly unless I actually cap the framerate. Eventually I settled on just using the 30FPS lock and V-Sync with the Ultra preset. Note that the Ultra preset doesn't actually set all settings to Ultra, just some of them, and even then it defaults to keeping the upscaling on so I had to turn it off. Setting everything to Ultra is a no-go with a 1070, but a mix of High and Ultra is giving me a rock-solid 30FPS, which I can live with.
There's some really ugly motion blur that apparently can't be turned off, unless I'm missing something. Characters are almost leaving Ninja Gaiden style after-images when they move; I had to double-check that I hadn't left the temporal upscaling thing on.