Well, lot of posters here are missing the point of why a 40 year old male may not relate to playing a teenage girl in video games.
It is not so much about the age and the gender of your character that these people don't relate to, but the world they encompass. The life they live, thier interests and the people that surround them.
Speaking from a personal experience. I am a minority, male in his late thirties. I did not grow up in a western society. My childhood and teenage years were very different than your typical North American (Westen) teenager. So... earlier this year I tried to play "Life is Strange" going into this game without knowing much about it, except the protogatist is a young, white girl.
30 minutes into the start of game, I felt very bored, very detached, and even mentally exhausted. I turned it off and never looked back. Why? Was it because the character I was controlling happened to be a teenage white female? No!
Because the game did everything in its power to force feed me the life of a contemporary, awkward, white girl in high school. Everything in the first 30 minutes offered in this game is about the main character, and who she is and the world she lives in, nothing really interesting about the world outside her little head.
I learned she's socially awkward, not the prettiest girl in class, but most likely one of the smarter ones, she likes photography and has a creative eye for it, hates how her young, pretentious, douchy, hipster male teacher gives more attention to the prettier girls in the class instead of her...The dialogue tried so hard to immerse the player in the benign, mundane world of a teenage female student. I felt restless, I wanted to get the hell out of that classroom ASAP and do some interesting stuff, but the game forced me to read my teenage girl diary, full of really teenage girly thoughts about romance, friendship, relationships. This shit just bummed and creeped me out. I felt like a creep going through a teenager's notes that were left behind on the table at a coffee shop. I never felt so detached and alienated from a video game before, and I thought to myself; Surely there is the right audience for this type of game/genre, but that player was not me... Just as the Disney channel has to be on in the house with all the Hannah Montana like shows while I'm babysitting my 8 and 10 year old nieces. I am forced to endure that, because it is there for the kids, not me, but I don't have to endure a game that makes me feel like I am watching an episode of iCarly, if I really don't want to.
On the same token, for those who are joking about not relating to a middle aged, Italian plummber... if Super Mario World was more like Dreaded Mario's World instead, where you were this struggling plumber in some poor Italian village, had hard time making ends meet, your wife resented you for your failures and most likely was cheating on you with your brother Luigi or the wealthier, docuhier guy named Bowser down the street. (The village bully/cop)
If that was the premise of Super Mario Bros/World... surely things would've been very different for Nintendo right now.
In a nutshell, a game's purpose, first and foremost is to exist for the gamer's pleasure and enjoyment. Not to judge or test the player's patience in accepting the world, the story and characters it conveys.
I wonder if Life is Strange is more than just about a teenage girl, and her diary... but I don't wonder enough to keep playing it to find out if it is worth another 5 minutes of my time. I got the gist of it, and it ain't for me, and dare I say, I don't fell one bit guilty for deleting it from my hard drive.
It's your life, your time, if you're not enjoying something because you cannot find any entertainment value to suit your taste, move on to something else, who gives the shit if the character is a teenage minority female, a white, middle aged, bald space marine or a fucking wombat!