You must be blind to not be able to see how that comment was meant to be derogatory, come on dude.
"Overwatch feels like it's kinda skewed to, you know, like..an anime-type vibe, right?"
That's pretty much the exact quote he used. In a separate interview he was talking about the whole "mature" thing. Two separate interviews, two contexts that are pretty much removed when you put them together. I think it's disingenuous and kind of pointless, but whatever.
As someone that doesn't care for anime but likes the character designs in Overwatch, I just don't see how that's derogatory. Isn't it entirely possible that maybe there are people out there that don't care for that aesthetic and dont necessarily have to shit on that aesthetic just because they don't like it? I just think it's weak to think that, just because maybe that's not the style he likes and the style he's going for, that automatically means he's shitting on people that like it.
What is so offensive about people thinking a game caters towards an anime audience? Unless you are making assumptions about anime audiences, I don't see how that's offensive in the slightest.