- I think it's set in a post-apocalyptic world where there's a corporation that uses babies to suck some kind of energy from, my guess is "Life Energy", (from their belly button? that's why Reedus' is stitched?).
- That "Life Energy" is used to control the dead or bring them back to life?
- Mads' character, the villain, is the head of said corporation.
- After sucking "Life" from the babies they're held captive, hence the handcuffs, till they grow up and then forced to produce new babies.
- Reedus somehow escapes.
- Del Toro looks like an employee of said corporation that's gone rogue and trying to save a baby. Maybe family.
EDIT:
- Maybe the trailer is a flashback and the baby that's Del Toro is saving is Baby Reedus?
- And Mad's character doesn't age because he's using that "Life Energy".
Which would explain it if he'd be there after ~20 years when Reedus is grown up.