It has to be Eternal Darkness 2.
1. Nintendo just renewed the Eternal Darkness trademark. This was just after renewing the Luigi's Mansion trademark and announcing Luigi's Mansion 2.
2. Denis Dyack hinting they are working on a highly requested game of theirs. I doubt Microsoft or anyone is excited about funding Too Human 2. Crystal Dynamics and Silicon Knights are not in working terms for Blood Omen (I think). Only option is Nintendo and Silicon Knights working on Eternal Darkness 2.
I see, Mischief Makers it is!