Whole plot outline for those interested
Ethan gets a message from his wife Mia who's been missing for 3 years. He goes it rescue her, but it turns out she's been infected by something that causes her to shift between her normal self and this crazy monster girl. Crazy Mia cuts off Ethan's hand, and after knocking her out, Ethan himself gets knocked out by Jack Baker.
Ethan wakes up in the Baker's main house, roams around, fights Jack a few times, and eventually makes it out to a different part of the Baker plantation, where he deals with Marguerite. Ethan then has to deal with Lucas trying to kill him in a series of traps, and he finds and frees Mia. Afterwards Ethan encounters Zoe, Jack and Marguerite's daughter who isn't crazy like the rest of them, but is still infected. Zoe has two serums that can cure the infection in people, but Jack Baker comes back super heavily mutated and Ethan is forced to use one of the serums on Jack, who is too far mutated to be cured and dies from the effects.
Ethan then has to pick who to administer the remaining serum to: Mia or Zoe. Either way, Zoe is killed by someone called "Eveline", and Ethan is captured by Eveline. The player then takes control of Mia as she goes to rescue Ethan from a ship that ran aground next to the Baker plantation. Along the way, we learn through documents Mia finds that Eveline is a self-aware BOW bred by a mysterious corporation who was going to sell it to the highest bidder, and that Mia was aboard the ship as some sort of handler for Eveline. Ethan is trapped in some mold and is experiencing some weird shared consciousness that involves all other people infected by the mold, where he has a meeting with Jack Baker, who explains that they took Eveline in, and that she infected them in order to turn them into some twisted sort of family. Eveline is revealed to be Grandma Baker, who has aged rapidly due to not being maintained by the corporation's handlers. Ethan is freed by Mia, and depending on if you cured her or not she dies sacrificing herself to save Ethan from Eveline.
Ethan obtains a super powerful version of the serum from the ship that can destroy Eveline, and makes his way through the plantation to confront her, learning along the way that Lucas was working with the mysterious corporation and that he managed to escape from the plantation before he could be confronted. Ethan injects Eveline, she turns into a giant monster, and Ethan is given a powerful experimental Samurai Edge to defeat her. It turns out Ethan is rescued by someone calling themselves "Redfield" (though people believe it's an impostor due to him not looking like or sounding like Chris), and Ethan is flown out on Redfield's helicopter, along with Mia if she didn't die. As the helicopter flies away, it's revealed that it's actually an Umbrella helicopter, leaving the game on a cliffhanger on why Umbrella is back.
Shame about Lucas.