Somewhat, but Uncharted is a more straightforward pulp adventure shooter vs. the more methodical & usually more stealthy survival horror approach of Last of Us. Whereas Last of Us is more about scrounging for any kind of supplies/weapons in your environment that can help you get an edge over your enemies and finding all of the ways to trick your opponents so that you can take them out as efficiently as possible, Uncharted is a bit more about just playing around with the weapon arsenal that the game offers you while fighting enemy waves that often force you to move around, less about trying to make the most out of limited supplies.
Oh, and bare in mind that Uncharted 1 can be a bit iffy by today's standards. It's a bit too heavily relient on fighting countless enemy waves in a single location before you can move on and those rooms & locations aren't quite as well designed as what Naughty Dog offers in the sequels. There's also less variety and not that many impressive gameplay scenarios that bring some much needed variety into the sequels. If you feel that Uncharted 1 is a bit of a bore, I'd say run through it on the easiest setting to get through it effortlessly and then continue on to Uncharted 2, the best game in the franchise so far.
