My dream is an open world RPG where you get to create your own mutant (like CoH/Champions Online). Give me dialogue choices, branching stories and the possibility of going villain and you have the Game of Forever.
The last time this was attempted, it was the game that literally killed the company that made it entirely.
Because that worked like gangbusters for Infinite Crisis.
Oh wait...
Infinite crisis shat the bed because instead of dipping into the IMMENSE pool of characters they have, DC stuffed the roster with just variations of batman, wonder woman, the joker and superman.
Marvel could do a MOBA that could sell well if they actually exploited their roster right.