There are entire websites already set up for starting this with active forums and groups and entire twitch groups who are planning to attempt it from day 0 moment 1.
As for getting tired. Sure. People get fucking tired putting on boxer shorts.
I don't see why people who really want to meet up would give up, unless they just got bored of the game altogether. I mean, meeting up with your friend would just involve playing the game mostly normally, but just trying to progress to the same general area.
Even with all of the preparation and planning, this game is immense. Like, really, really fucking huge. I don't think people are really going to understand how gargantuan of a task this is going to be until they are actually inside the game, on a planet, and they realize that when they pull out to the galaxy map, there are literally billions and billions of stars between them and their friend.
We don't know how the tracking system works in this game. That is to say, do we know the relationship between the star system you're currently in, the star system your friend is currently in, and how you'd chart a course to each other's star system. Is there an overall galaxy map that will say, "You are in Novigraad, your friend is in Skellige, and this how far away they are from one another?" I can't say that kind of map isn't in the game, but I can't say it is either. I feel like the confident, "We'll organize a meetup group," is going to be easier said than done.
This game doesn't appear to have a system like in The Witcher, where you can just drop a marker on the map, and then follow the dotted line to that marker. There is a line pointing towards the center of the universe, and a line pointing towards the nearby star systems you can reach with your current hyperdrive given sufficient fuel. No one is saying people can't meet up with each other, just that it's not going to be easy, and I doubt people are going to be pulling it off a week or two after release.
Again, you can tell your friend, "I'm in the Hoth system," and he can tell you, "Well, I'm in the Dagobah system," but without knowing where those two systems are in relation to one another, it's not really going to help you much. I'd need to know if there is a general universe map, that shows you EVERY star in the entire game (like the World Map in the Witcher 3), or if you're map is only going to show your immediate location. The videos we've seen have had Sean using a debug build that let him pull further and further out of the galaxy and immediately select another star to reach. But that's a debug build. I'm not trying to shit in anybody's cereal, because I really want to see two players meet one another, because I more than likely never will, but I think the realities of the scale of the universe in the game is going to shock people when they can experience it first hand.
EDIT: I also wonder, if there is a universe map, if you can highlight the different stars and see the system names. You know that video where Sean pulls out and shows all of the stars, can you select one and see their data? Is the universe split into quandrants that you can identify? It'll be a lot easier to find a friend if the map can tell you, "You are in the Alpha Quadrant, and your friend is in the Beta Quadrant," and you can see where those quadrants are. Then you could chart a course for the Beta Quadrant, and then narrow the star systems down bit by bit until you reach the same system, then narrow it down more until you reach the same planet/space station, and ideally meet up.
