I was soured on the Fallout 4 experience, like many here. Got caught up in the hype, bought it at launch during a time when the (vastly superior) Witcher 3 was blowing my mind, and quickly realized Fallout 4 was an uninspired "go here, kill that" simulator and nothing more.
The lack of deeply structured and meaningful quests is the biggest piss off. The game's main campaign and character are laughable. The lazy "RPG-lite" mechanics leave a lot to be desired.
However, jumping back into my original save from time to time with my expectations for what a Fallout game should be (NV) dialed way back, I have a pretty good time with this. It does a pretty good job of creating atmosphere, especially with a few mods implemented, and so I find myself enjoying it on a more superficially visceral level.
Basically, treat it as a post-apocalyptic action exploration game; just wander around and see what finds you. You'll have more fun that way.
I'm perfectly fine with vanilla as there is plenty of content and apparently the DLC is barely worth a damn.
GOTY my ass, though.